Leukopenia as you said, means low WBC’s (leukocytes) and indicates a decrease in disease-fighting cells in the human blood. It can cause potentially a serious complication that if untreated could be detrimental for you. It could represent a mild infection. The conditions that cause leukemia are: Autoimmune conditions (lupus, HIV), bone marrow damage, chemotherapy, radiation therapy, exposure to toxins, bone marrow disorders, leukopenia, lymphoma, sepsis (severe infection) vitaminB12 deficiency and others. Life-threatening infections such as sepsis and septicemia can occur. Positive ANA means that antinuclear antibodies are found in your blood. A positive result can indicate Systemic Lupus Erythematosus (SLE). In viral infections antinuclear antibodies from the virus are usually temporary. There are other diseases that can cause positive antinuclear antibodies. They are SLE, Sjogren’s syndrome, scleroderma, or mixed connective tissue disease. Antinuclear Antibodies are proteins produced by your immune system. Please, make an appointment to see hematologist or a hemato oncologist for a thorough examination..