I would avoid taking an NSAID which includes Ibuprofen, Aleve, Advil, Naproxen... during an allergic reaction as it can lower your threshold for anaphylaxis a more severe systemic allergic reaction. If needing pain control then I would recommend Tylenol instead. Ibuprofen and Cetirizine do not interact, they are otherwise safe to take at the same time, outside of when you are experiencing an allergic reaction. Sterling Kosmach, DO Allergist Aspire Allergy Sinus Out of Office Thursdays and Fridays Office 866 5261499 Fax 8558280878 sterling.kosmachaspireallergy.com AspireAllergy.com CONFIDENTIALITY NOTICE This communication and any attachments may contain confidential andor privileged information for the use of the designated recipients named above. If you are not the intended recipient, you are hereby notified that you have received this communication in error and that any review, disclosure, decimation, distribution or copying of it or its contents is prohibited. If you have received this communication in error, please notify the sender immediately by telephone and destroy all copies of this communication and any attachments.