Dr. Darren N. Seril, M.D., PhD

Expert Publications

• Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.
• Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols.
• Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice.
• Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine.
• Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models.
• Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice.
• Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in
• Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet.
• High-iron diet: foe or feat in ulcerative colitis and ulcerative colitis-associated carcinogenesis.
• Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis.
• Mycobacterium avium Subspecies paratuberculosis in Crohn's disease: the puzzle continues.
• The association between autoimmunity and pouchitis.
• Clostridium difficile infection in patients with ileal pouches.
• Risk factors and management of refractory or recurrent clostridium difficile infection in ileal pouch patients.
• Auto-inflammatory diseases in ileal pouch patients with NOD2/CARD15 mutations.

Clinical Trials

• An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

Media Releases

Get to know Gastroenterologist Dr. Darren N. Seril, who serves patients in New Brunswick, New Jersey.

Dr. Seril is a dual board-certified, fellowship-trained gastroenterologist on staff at the Robert Wood Johnson University Hospital New Brunswick.

The Robert Wood Johnson University Hospital is an American 965-bed hospital with campuses in New Brunswick and Somerville, New Jersey. It serves as a flagship hospital of RWJBarnabas Health. “Our mission is to improve the health and well-being of the patients and communities we serve by: Fostering an environment of excellence in all areas including the provision of the highest quality, evidence-based patient care in collaboration with the hospital’s health care professionals.”

His acclaimed field in medicine began after he obtained his medical degree from Rutgers Robert Wood Johnson Medical School in 2007. He then went on to serve his residency in internal medicine at Thomas Jefferson University Hospital. This was followed by fellowships in inflammatory bowel disease and gastroenterology at Cleveland Clinic Foundation and Rutgers Robert Wood Johnson Medical School, respectively.

A leader in his field, Dr. Seril is board-certified in internal medicine and gastroenterology by the American Board of Internal Medicine (ABIM). The ABIM is a physician-led, non-profit, independent evaluation organization driven by doctors who want to achieve higher standards for better care in a rapidly changing world.

Gastroenterology is the branch of medicine focused on the digestive system and its disorders. A gastroenterologist is a physician who has extensive training in the diagnosis and treatment of disorders related to the esophagus, stomach, small intestines, colon, liver, pancreas, and biliary system.

In honor of his clinical expertise, Dr. Seril is the recipient of Patients’ Choice Award (2016) and On-Time Doctor Award (2016).

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