Exploring the Safety of Suboxone: A Promising Alternative in Addiction Treatment

JORDYN L MASTRODOMENICO Counselor/Therapist Fair Lawn, NJ

Jordyn Mastrodomenico is a counselor in New Jersey. She evaluates patients using many different procedures, in order to determine what treatments must be carried out in order to properly assess their symptoms. Counselors provide consultation for each patient and their families.

Opioid use disorder is a debilitating SUD. Not having appropriate treatment can be quite dangerous. In the battle against opioid addiction, it is important to find effective and safe treatments. In recent decades, Suboxone has gained the utmost attention for its potential to offer a safer alternative than other existing treatments. But what exactly sets Suboxone apart from other options, and why is it considered a safer choice for individuals struggling with opioid dependence?

Understanding the Opioid Epidemic

Before going into the specifics of Suboxone, it's crucial to understand the extent to which opioid use disorder caused havoc in the US. Opioid addiction has reached crisis levels globally, causing many people to lose their lives or affect them in different ways. 

Traditional treatments often involved medications like methadone, buprenorphine, and naltrexone. Suboxone was created in a way to reduce the risk of misuse. While other treatments are effective, they also come with their own set of challenges, including a high risk of abuse and overdose. But how is Suboxone more effective?

Aspect

Methadone

Suboxone

Naltrexone

Mechanism of action

Full opioid agonist, activating opioid receptors

Partial opioid agonist + antagonist activates and blocks opioid receptors

Opioid antagonist blocks opioid receptors

Administration

Oral solution or tablet, administered daily in a clinic setting

Sublingual film or tablet, taken daily or less frequently

Oral tablet, taken daily

Risk of Abuse

High risk due to being a full opioid agonist

Lower risk due to being a partial agonist

Low risk due to its antagonistic action

Overdose Risk

Moderate risk, especially during initiation

Lower risk due to ceiling effect on respiratory depression

Using opioid while on naltrexone can result in overdose or death

What is Suboxone?

Suboxone is a medication that combines two active ingredients: buprenorphine and naloxone. Buprenorphine is a partial opioid agonist, meaning it activates the opioid receptors in the brain but to a lesser extent than full agonists like heroin or oxycodone. Naloxone, on the other hand, is an opioid antagonist, designed to block the effects of opioids and prevent misuse. Suboxone is prescribed by Suboxone doctors online and at registered clinics.

The Safety of Suboxone: A Comparative Analysis

Naloxone is passive in the sense that it doesn't have pharmacological effects on the body beyond reversing opioid overdose. Suboxone is a medication used to treat opioid addiction, and it contains both buprenorphine, which helps reduce cravings and withdrawal symptoms, and naloxone. 

Naloxone is included in Suboxone primarily to deter misuse via injection. If someone attempts to inject Suboxone, the naloxone component will counteract the effects of the buprenorphine, potentially leading to withdrawal symptoms in opioid-dependent individuals. This deterrent effect can help discourage the misuse of Suboxone.

Reduced Risk of Overdose

One of the most significant advantages of Suboxone is its reduced risk of overdose compared to other opioids. Because buprenorphine is a partial agonist and it has a ceiling effect it means that taking more of it does not produce a proportional increase in the effects. This limits the risk of respiratory depression, a primary cause of fatal opioid overdoses. Also, naloxone in Suboxone will deter misuse by inducing precipitate withdrawal. 

Lower Potential for Abuse

Unlike full opioid agonists, which can produce euphoria and a strong reinforcing effect, buprenorphine's effects plateau at a certain point. This makes it less likely to be abused or diverted for non-medical use.

Safer Administration

Suboxone is typically administered as a sublingual film or tablet, reducing the risk of needle-related infections and complications associated with intravenous drug use. This not only enhances the physical safety of the individuals but also reduces the transmission of blood-borne diseases commonly associated with intravenous drug use. 

Also, sublingual administration diminishes the likelihood of accidental overdose, a critical concern in the context of opioid addiction treatment. Overall, Suboxone's sublingual formulation represents a significant advancement in promoting the well-being and safety of individuals navigating the complexities of opioid dependence.

Dual Action of Naloxone

Including naloxone in Suboxone serves as an added safety measure. If someone were to misuse Suboxone by injecting it intravenously, the naloxone would counteract the effects of buprenorphine, precipitating withdrawal symptoms and discouraging further misuse.

Can You Take Suboxone While Pregnant?

Suboxone is a safer alternative to other medications as well as OUD. In some cases, there have been issues with the infant, but generally, it is considered safer. One of the studies suggests that if a pregnant individual is already stable on buprenorphine-naloxone therapy, there might not be a need to switch to a different opioid medication that has a higher potential for abuse. This is significant because maintaining stability on a medication that is safer and less prone to abuse can contribute to better outcomes for both the pregnant individual and their baby. Having said that, it is important to undergo the treatment from an addiction specialist to ensure safety. 

Addressing Potential Concerns

While Suboxone offers several advantages in terms of safety, it's essential to acknowledge that no medication is without its drawbacks. Some individuals may experience side effects such as nausea, constipation, or headache. Additionally, there is a potential for dependence on Suboxone itself, although this is generally considered less harmful than continued opioid misuse.

Due to all these issues, it is still considered a controlled substance and you need a prescription to attain it from the pharmacist. While DEA has improved its accessibility, it is still an issue for many people as it is not easily available at every pharmacy, and usually, people face its shortage. In such cases, talk to your healthcare provider for a different alternative of the same formula. 

Takeaway

Suboxone represents a significant step forward in terms of safety and effectiveness in the face of the extreme opioid epidemic. By combining the partial opioid agonist buprenorphine with the opioid antagonist naloxone, Suboxone offers a unique approach to managing the opioid dependence while minimizing the risk of overdose and abuse. While further research and education are needed to optimize its use, Suboxone holds promise as a safer alternative in addiction treatment, offering hope to individuals seeking to reclaim their lives from the grip of opioid addiction.