“High liver enzymes?”

Elevated enzymes might be discovered on routine blood testing. Meaning the ALT, AST, ALP, and GGT are elevated. Evaluation of abnormal liver enzymes levels in a otherwise healthy patient can pose a challenge to even an experience clinician. A comprehensive investigation combining thorough history-taking and physical examination, along with diagnostic tests, liver biopsy and imaging. Most of the time a liver biopsy would give you a more reliable diagnosis. Specially when the pathologist will be examining the tissue (liver)biopsy. Sometimes it is very puzzling because the elevation of these enzymes is transitory. Patterns reflecting predominantly hepatocellular injury is elevation of ALT/AST +/- elevation of bilirubin. Patients reflecting cholestasis presents with elevation of ALP =/- elevation of ALP. For mixed disease presentation is elevation of ALT/AST and ALP. Now, ALT = alanine aminotransferase, AST = Aspartate aminotransferase, ALP = Alkaline Phosphatase. I believe that a liver biopsy would be paramount on this conundrum. Thank you.

You are on medicines that may increase your enzymes. If still high and your doctors are clueless, they may need to have your liver biopsied. There are more specialized blood tests that may answer some questions.
Good luck.

RB thomas, MD