Aubagio

Teriflunomide is used for treatment of multiple sclerosis relapse. The exact mechanism of action of the drug is uncertain. However, it is presumed to involve a reduction in the number of activated lymphocytes in the central nervous system.

This product is available in tablet.

Tell to your doctor if you are allergic to Teriflunomide or to any other medications. You should also inform your healthcare providers if you are allergic to foods, dyes, or animals.

Safety and effectiveness of this medication have not been established in children.

Pregnancy category X - Do not use these medications if you are pregnant or expecting a baby because this medication can cause fetal abnormalities.

There are no adequate studies whether Teriflunomide can pass through breast milk or if it could cause harmful effects to the infant. Discuss with your doctor if you are breastfeeding a baby.

Taking this medicine with Leflunomide is not recommended and you may not be required to receive this medication. Otherwise, alternative medicine may be prescribed for your other medications.

Taking this medicine with any of the following medicines is usually not recommended, but with exception in some cases. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

• Adenovirus Vaccine Type 4, Live
• Adenovirus Vaccine Type 7, Live
• Bacillus of Calmette and Guerin Vaccine, Live
• Influenza Virus Vaccine, Live
• Measles Virus Vaccine, Live
• Methotrexate
• Mumps Virus Vaccine, Live
• Poliovirus Vaccine, Live
• Repaglinide
• Rosuvastatin
• Rotavirus Vaccine, Live
• Rubella Virus Vaccine, Live
• Smallpox Vaccine
• Typhoid Vaccine
• Varicella Virus Vaccine
• Warfarin
• Yellow Fever Vaccine

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

• Bone marrow problems
• Hyperkalemia
• Hypertension
• Liver disease
• Lung disease
• Peripheral neuropathy 
• Tuberculosis
• Weak immune system
• DiabetesInfection, active
• Kidney disease
• Severe liver disease - Should not be used in patients with this condition.

Use Teriflunomide exactly as prescribed by your doctor. Excessive use of medication is not recommended. This medication can be taken with or without food.

This medicine may stay in the blood for up to 2 years after the treatment. Activated charcoal or cholestyramine may be recommended to help remove this medicine from the body much faster if necessary. 

The dose of this medicine varies for different patients. Recommended dosage for adults is 7 mg/day or 14 mg/day.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light.

Keep out of reach of children.

Do not keep expired medications.

Check with your doctor if you are having any of the following:

• If you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet since this medication may cause peripheral neuropathy.
• If you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, fever or chills since this medication may cause serious skin reactions.
• If you have a cough with or without a fever or trouble breathing while taking this medicine.
• If you notice any change to your recommended blood pressure.
• If you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin since this medicine may cause serious liver problem. 

Your doctor will be checking you regularly to monitor the effectiveness of the medication. Blood tests may be ordered for undesirable effects.

Contraceptives must be used to keep you or your partner from getting pregnant. Tell your doctor immediately if you think you have become pregnant while using this medication.

Avoid using this medication with leflunomide. Using these medicines together may cause serious undesirable effects.

Skin test is recommended before using this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis test.

Do not receive any vaccinations without your doctor’s approval while you are under Teriflunomide treatment.

Teriflunomide may increase your risk of getting cancers. Talk to your doctor if you have concerns about matter.

Do not take other medicines unless they have been discussed with your doctor.

Teriflunomide can lower your body’s resistance temporarily as well as your platelet count. To reduce the risk of bleeding and infection, these certain precautions should be followed:

• Avoid coming into close contact with sick people. 
• Consult with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
• Be cautious when using a regular toothbrush, dental floss, or toothpick.
• Use protective equipment such as mask for added protection.
• Avoid activities that might cause injuries.

If any of the following side effects occur, check with your doctor right away:

• Body aches or pain
• Burning, Crawling, Itching, Numbness, Prickling, "Pins and Needles", or Tingling feelings
• Chills
• Cough
• Cough producing mucus
• Diarrhea
• Difficulty breathing
• Ear congestion
• Fever
• General feeling of discomfort or illness
• Headache
• Joint pain
• Loss of appetite
• Loss of voice
• Muscle aches and pains
• Nasal congestion
• Nausea
• Runny nose
• Shivering
• Sneezing
• Sore throat
• Sweating
• Tightness in the chest
• Trouble sleeping
• Unusual tiredness or weakness
• Vomiting
• Abdominal or Stomach pain or tenderness
• Agitation
• Black, Tarry stools
• Bloody or Cloudy urine
• Blurred vision
• Burning, Numbness, Pain, or Tingling in all fingers except smallest finger
• Clay colored stools
• Coma
• Confusion
• Dark urine
• Decreased appetite
• Decreased urine output
• Depression
• Diarrhea
• Difficult, Burning, or Painful urination
• Dizziness
• Fast, Irregular, Pounding, or Racing heartbeat or pulse
• Frequent urge to urinate
• Hostility
• Irritability
• Itching or Skin rash
• Lethargy
• Loss of appetite
• Lower back or side pain
• Muscle twitching
• Pale skin
• Pounding in the ears
• Rapid weight gain
• Seizures
• Slow or Fast heartbeat
• Stupor
• Swelling of the feet or lower legs
• Ulcers, Sores, or White spots in the mouth
• Unusual bleeding or bruising
• Weakness or Heaviness of the legs
• Yellow eyes or skin
• Blistering, Peeling, or Loosening of the skin
• Joint pain
• Red skin lesions, often with a purple center
• Red, Irritated eyes

Less serious side effects:

• Hair loss or thinning of the hair
• Blemishes on the skin
• Bone pain
• Burning, Dry, or Itching eyes
• Difficulty with moving
• Discharge or Excessive tearing
• Full or Bloated feeling
• Muscle cramping or stiffness
• Pain in the lower back, bottom, or hips
• Pain in the upper leg
• Pimples
• Pressure in the stomach
• Redness, Pain, or Swelling of the eye, eyelid, or inner lining of the eyelid
• Swelling of the abdominal or stomach area
• Swollen joints
• Toothache
• Weight loss

Not all side effects are listed above. If you notice any other effects, check with your healthcare professional.