Prezista is a protease inhibitor used to treat HIV. It should be taken concomitantly with ritonavir and other antiretroviral drugs.
This medication can be given to patients who have received previous treatment for HIV as well as patients who have not received prior treatment.
It is important to remember, however, that darunavir will not cure HIV or prevent you from spreading the disease although it will prevent or delay the development of HIV-related problems.
This medicine also inhibits the reproduction of HIV cells and slows down the destruction of your immune system. Prezista is a prescription medication and is sold as a tablet or a suspension.
If you are about to start Prezista, speak with your doctor about what you need to know. You and your primary physician need to discuss the pros and cons of using Prezista before starting treatment.
There are also several factors you need to think about. If you’ve had hypersensitivity reactions to darunavir or any of its ingredients, inform your doctor. Also, tell him/her if you have allergies to food, preservatives, dyes, animals or other medicines.
Studies have shown that darunavir does not cause pediatric-specific effects in children ages 3 and above. However, it should not be used in those younger than 3 years old because of its toxicity.
Studies have also found that darunavir doesn’t cause geriatric-specific effects although it should still be used with caution in elderly patients since they are more at risk of liver-related problems.
Darunavir has a pregnancy category C meaning there hasn’t been enough research done regarding its effects on the unborn child. The same goes for breastfeeding. You must carefully consider the pros and cons.
Give your physician a complete list of your medications. Darunavir can interact with different medicines and cause harmful side effects.
The following should not be used concomitantly with darunavir:
alfuzosin
astemizole
colchicine
dihydroergotamine
domperidone
ergonovine
ergotamine
lomitapide
midazolam
pimozide
sildenafil
simvastatin
terfenadine
triazolam
On the other hand, the following medications are usually not recommended but can be necessary:
amineptine
apixaban
atomoxetine
budesonide
butalbital
clozapine
cyclophosphamide
dasabuvir
delavirdine
dibenzepin
doxepin
drospirenone
eliglustat
erythromycin
ethynodiol diacetate
fluticasone
haloperidol
imipramine
lumacaftor
mephobarbital
nafcillin
naloxegol
nilotinib
norgestimate
oxcarbazepine
oxycodone
piperaquine
primidone
quetiapine
rivaroxaban
secobarbital
tamoxifen
vardenafil
vinblastine
vincristine
Other medications can also increase the risk of certain side effects:
clarithromycin
cobicistat
digoxin
indinavir
ketoconazole
fumarate
Darunavir can make the following conditions worse:
Darunavir should not be used in patients with severe liver disease and should be used with caution in those with sulfa allergies.
3 Proper Usage
To use Prezista properly, you must follow all instructions given by your doctor. You should never change the dosage or timing without consulting your physician first.
If your supply is low, contact your doctor as soon as you can. Darunavir should always be taken with ritonavir unless stated otherwise.
This medicine should be taken with food and it should be swallowed whole, not crushed or chewed.
The dosage will depend on your condition.
For adult patients without darunavir resistance associated substitution, it is 800 mg.
For pediatric patients without darunavir resistance associated substitution, the dose will depend on their body weight.
For adult patients with darunavir resistance associated substitution, the dose is 600 mg.
For pediatric patients, it also depends on the body weight.
For patients who haven’t had previous HIV treatment, adults get 800 mg and children’s dose will depend on body weight.
Store your medicine in a safe place that’s out of children’s reach. For those taking the darunavir once a day and you miss the dose, take it as long as the next dose is more than 12 hours away. Otherwise, skip it and resume normal timing.
For those taking this medicine twice a day and miss a dose, take is as long as the next one is more than 6 hours away. Otherwise, skip it and resume normal timing.
4 Precautions to Take
Before using Prezista, there are some precautions you must take. Go to your follow-up checkups religiously so that your physician can monitor your progress.
You may also need to get regular laboratory tests done. Do not take nonprescription medication or supplements without check with your doctor first.
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