Hematologist-Oncologist Questions Blood Clots

What causes a clotting disorder?

I'm 19 and have a clotting disorder. I do have a family history of blood clots from my grandfather (maternal) and my mother. However, my mother only had clots in her legs and when she was pregnant. Well, I'm not pregnant and my clots like to form in my lungs. Currently I'm on Arixtra. Could clotting disorders be genetic?

3 Answers

Yes, there are congenital clotting disorders which are very rare. Most clots start in the legs or the ovarian veins from trauma and then travel to the lungs.
The congenital clotting disorders include Factor V Leiden, Prothrombin Gene Mutation and Antithrombin Deficiency. Clotting is also increased in the antiphospholipid syndrome.
Sounds like you have a genetic cause of hypercoagulation. They include antithrombin III, protein C, protein S, Factor V Leiden (the most common 7% of the caucasian population), prothrombin G 20210A (the next most common), hyperhomocystemia, abnormal fibrinogen. In addition, the tendency to have autoimmune disorders and antiphospholipid antibodies does exist genetically and they can cause clots.
It certain can be and often is genetic. You should have been investigated for such a disorder, of which there are many, to isolate the cause and determine its potential for siblings and offspring passage.