Colon and Rectal Surgeon Questions Colon and Rectal Surgeon

Please help re: metastatic disease?

My sister discovered nearly 20 years ago that she acquired HPV (Human Papilloma Virus), which was shortly after getting involved with her husband. (He's had one previous girlfriend that I'm aware of.) In 2017, she found blood in her stool and was diagnosed with stage 3B colorectal cancer. They did a hereditary test to determine if it was genetic and it was not. She's also had a life-long clean bill of health. She deserted her family soon after diagnosis and we haven't heard anything from her husband still to this day.

I'm convinced her cause of cancer is from HPV, due to being extremely healthy with no comorbidities, proof that it’s not familial, as well as her behavior of estranging us (out of embarrassment.) I ordered a copy of her death certificate which states the Cause of Death Line A is Metastatic Rectal Cancer. Indeed, it was since it spread to the lymph nodes. However, the Cause of Death Line B lists Metastatic Disease. If Line B signifies a precursor to Line A, then isn't it correct that the metastatic disease would be HPV that was metastatic in the sense that a disease transferred from one body to another? I looked up the definition of metastatic and it mostly refers to inside the body, but it sounds as though this definition can also be applied to outside the body.

I'd like to know if my assumption on her cause of death is correct as I can't seem to find any coroners or help on this. Also, do coroners typically not list HPV as an underlying reason due to hiding embarrassment for the deceased? Or, could she have requested to her doctor that they not report HPV so that no one knows? I'm not looking to hold anyone accountable. I’d just like to finally have this "unknown" answered to be able to put this to rest and move on with life.

Female | 47 years old
Conditions: Metastatic disease

3 Answers

HPV is not known to cause colorectal cancer. It could cause cervical cancer or anal cancer.
She was cured from HPV. She died from metastatic colorectal cancer.
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HPV has been associated with cancer of the colon and rectum, but it is not common. HPV is not looked for except in cancer of the cervix and anus (not the rectum) and cancer of the oral cavity. The original rectal cancer specimen could be tested for HPV but that would not be covered by insurance and would cost several hundred dollars. If HPV was proven to be present in the rectal cancer, unfortunately there would be a lot of skepticism that it caused the cancer.
Metastasis refers to the cancer being spread, not to the virus.