“What is the strongest over the counter pain reliever for a toothache?”

Ibuprofen

Combination of ibuprofen and Tylenol.

Medlineplus.gov › Health Topics explains "There are two main types of OTC pain medicines: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs." Each of these have different efficacy in different people and in treating different sources or causes of pain. Aspirin works by blocking the production of prostaglandins, the on-off switch in cells that regulate pain and inflammation, among other things. NSAIDs act both locally (at the site of the pain) and centrally (where the pain registers in the brain) Acetaminophen relieves pain by elevating the pain threshold in the central nervous system but not peripheral tissues, that is, by requiring a greater amount of pain to develop before a person feels it. Since there is often an inflammatory, or swelling, component to dental pain NSAIDs are typically highly effective in reducing/relieving dental pain. People find different NSAIDs work better for them than others. Some find naproxin more effective than ibuprofen and others find just the opposite. Combining medications of the same class increases the risk of negative side effects so should typically be avoided. Combining medications of different classes can often result in the benefits of all the medications without increasing the risk of negative side effects. Research has shown repeatedly that combining 600 mg Ibuprofen with 500-1000 mg acetaminophen is as effective as narcotic medications in reducing and relieving pain. I regularly recommend 600 mg ibuprofen with one extra strength Excedrin for pain relief. Excedrin is a combination drug containing Aspirin, Acetaminophen, and caffeine. By taking Excedrin with ibuprofen you take advantage of blocking multiple different pain pathways as well as get the effect of the caffeine, which often accelerates the action of medications taken concurrently. Long way to say. In my experience, taking 600 mg ibuprofen with one Excedrin (or generic equivalent) is the most effect and fastest acting pain relief for those without adverse reaction to any of the ingredients.

Hi,

If you are not allergic, you can take 2-4 ibuprofen (Advil or Aleve) plus an extra strength Tylenol together. This is equivalent to a Vicodin opioid, but without addictive properties. Or Oragel may help, too.

Aleve - 2 tabs. or ibuprofen a total of 800mg

Combination of ibuprofen and acetaminophen is the gold standard. Max of 2400mg ibuprofen daily. 1400mg for acetaminophen.

Ibuprofen 600 mg is the best over the counter pain relief

Most over the counter meds are ineffective including Orajel. For SHORT term relief with over the counter meds you can use a combination of 500mg tylenol, 600 mg advil and one type of ingestion of caffeine including coffee, chocolate, ect. This is only to be used until you can seek professional dental care since this combination taken more than a day or 2 can cause other major issues.