Pletal

Pletal is a quinolinone derivative that is used to treat symptoms of claudication caused by poor circulation by improving the blood flow through blood vessels.

Pletal works by keeping blood from clotting and by dilating or relaxing the blood vessels. This drug requires a prescription.

If you are about to start Pletal, speak with your doctor about what you need to know. Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

• Studies have not been performed on the relationship of age to the effects of cilostazol in the pediatric population while safety and efficacy have not been established.
• Studies regarding geriatric-specific problems that would limit the usefulness of cilostazol in the elderly have not been demonstrated.
• Adverse effects have been described in animal studies but there are no adequate studies in pregnant women or animals.
• Studies still cannot determine the development of infant risk when taking this drug during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if are taking any other drugs such as:

• Abciximab
• Abiraterone
• Aceclofenac
• Acemetacin
• Alipogene
• Tiparvovec
• Alteplase
• Recombinant Amiodarone
• Amtolmetin Guacil
• Anagrelide
• Aprepitan
• Aspirin
• Atazanavir
• Bitter Orange
• Boceprevir
• Bromfenac
• Bufexamac
• Celecoxib
• Ceritinib
• Choline Salicylate
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clonixin
• Clopidogrel
• Cobicistat
• Conivaptan
• Crizotinib
• Dabrafenib
• Delavirdine
• Desvenlafaxine
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Diflunisal
• Diltiazem
• Dipyridamole
• Dipyrone
• Dronedarone
• Droxicam
• Duloxetine
• Eptifibatide
• Erythromycin
• Escitalopram
• Eslicarbazepine Acetate
• Esomeprazole
• Etodolac
• Etofenamate
• Etoricoxib
• Etravirine
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Floctafenine
• Fluconazole
• Flufenamic Acid
• Fluoxetine
• Flurbiprofen
• Fluvoxamine
• Fosaprepitant
• Ginkgo
• Ibuprofen
• Ibuprofen Lysine
• Idelalisib
• Imatinib
• Indinavir
• Indomethacin
• Itraconazole
• Ketoconazole
• Ketoprofen
• Ketorolac
• Lansoprazole
• Letrozole
• Levomilnacipran
• Lopinavir
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Meclofenamate
• Mefenamic Acid
• Meloxicam
• Miconazole
• Mifepristone
• Milnacipran
• Moclobemide
• Morniflumate
• Nabumetone
• Naproxen
• Nefazodone
• Nelfinavir
• Nepafenac
• Netupitant
• Niflumic Acid
• Nilotinib
• Nimesulide
• Omeprazole
• Oxaprozin
• Oxcarbazepine
• Oxyphenbutazone
• Pantoprazole
• Parecoxib
• Paroxetine
• Phenylbutazone
• Piketoprofen
• Piperaquine
• Piroxicam
• Posaconazole
• Prasugrel
• Proglumetacin
• Propionic Acid
• Propyphenazone
• Proquazone
• Rabeprazole
• Regorafenib
• Ritonavir
• Rivaroxaban
• Rofecoxib
• Salicylic Acid
• Salsalate
• Saquinavir
• Sodium Salicylate
• Sulfinpyrazone
• Sulindac
• Telaprevir
• Telithromycin
• Tenoxicam
• Tiaprofenic Acid
• Ticagrelor
• Ticlopidine
• Tipranavir
• Tirofiban
• Tolfenamic Acid
• Tolmetin
• Valdecoxib
• Venlafaxine
• Verapamil
• Vilazodone
• Voriconazole
• Vortioxetine

Inform your healthcare professional if you are taking any other drugs. Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as active bleeding, blood clotting problems, congestive heart failure, heart rhythm, ischemic heart disease, leukopenia, liver or kidney disease, or thrombocytopenia.

Proper usage of Pletal requires strict adherence to your doctor’s orders. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed.

Refrain from eating grapefruit or drinking grapefruit juice while you are taking this drug.

The dosage of this medicine will be different for different patients. The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

• Adults with peripheral vascular disease are prescribed with 100 milligrams taken two times a day, taken at least one-half hour before or 2 hours after breakfast and dinner. If this drug is taken at the same time with other drugs, the dose may be reduced to 50 mg two times a day.
• Use and dose for children must be determined by a healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

Before using Pletal, there are some precautions you must take. Regular visits and laboratory tests should be made to your healthcare provider to track your progress and to monitor the effectiveness of this drug as well as check for unwanted effects.

• Consult your healthcare professional about a way to prevent bleeding and acquiring an infection as this drug can make you more prone to infection and bleeding.
• Inform your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
• Avoid contact sports or other situations where bruising or injury could occur.
• Dizziness, lightheadedness, or even fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve dizziness or lightheadedness.
• Smoking tobacco products, such as cigarettes, may worsen your condition since nicotine may further narrow blood vessels and may also affect how this medicine works. Therefore, it is best to avoid smoking.
• Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription drugs, and herbal or vitamin supplements.

As with many medications, there are several potential side effects associated with Pletal. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Inform your healthcare professional if you have symptoms of:

• fast or irregular heartbeat
• fever
• abnormal bleeding
• bloody or black tarry stools
• bruises or red spots on the skin
• fainting
• nausea
• heartburn or indigestion
• nosebleeds
• stiff neck
• stomach pain
• cramping or burning
• swelling of the tongue
• vomiting of blood or material that looks like coffee grounds
• abdominal or stomach pain area
• rash
• bleeding gums
• the bleeding tendency
• blistering, peeling, loosening of the skin
• blood in the urine or stools
• blurred vision
• chest pain
• chills clay-colored stools
• confusion
• a cough or hoarseness
• coughing up blood
• dark urine
• diarrhea
• the difficulty with breathing
• drowsiness
• fever with or without chills
• the general feeling of tiredness or weakness
• headache
• sudden and severe inability to speak
• itching of the eyes
• itching of the skin
• joint or muscle pain
• light-colored stools
• loss of appetite
• loss of consciousness
• lower back or side pain
• nausea and vomiting
• painful or difficult urination
• pinpoint red spots on the skin
• red skin lesions, often with a purple center red
• irritated eyes
• seizures
• skin rash
• slurred speech
• sores, ulcers or white spots on the lips or in the mouth
• stomach pain
• swollen glands
• temporary blindness
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• weakness in the arm or leg on one side of the body
• the sudden and severe weakness of part of the body
• yellow eyes or skin

Contact emergency medical services if symptoms of overdose occur such as:

• Diarrhea
• Dizziness or lightheadedness when getting up from a lying or sitting position
• Fast or irregular heartbeat
• Headache

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.